Probiotics: A Novel Therapeutic Strategy for Psoriasis Treatment

Psoriasis is an autoimmune, long-lasting, multifactorial skin disease. Studies on psoriasis have revealed that no treatment has been developed that can fully cure it. Moreover, the available topical and oral treatment options provide symptomatic relief. Clinically accepted biologicals remain uneconomical. It significantly affects the patient’s quality of life. A thorough analysis of the literature on psoriasis has led to the identification of a potential alternative strategy and the need for new formulation development. A recent study by researchers highlights that the human micro-biome differs between individuals based on Human Genome Project findings. The body’s microbiome interacts with the immune system to regulate autoimmune diseases. Psoriasis shows immune system imbalance due to gut and skin dysbiosis compared to a normal microbiome. Probiotics administered as food supplements can regulate the immune system. Probiotics produce antimicrobial substances, stimulate immunoglobulins, synthesize vitamins, and reduce intestinal permeability. They enhance epithelial barrier function and remove pathogens through competitive exclusion. Evidence from both preclinical and clinical research suggests that probiotics hold promise in psoriasis treatment. This review explores the use of probiotics in psoriasis management, suggesting that it could emerge as a future therapeutic avenue for treating psoriasis.