40 Hz Transcranial Alternating Current Stimulation Improves Motor Function in MCAO Mice and Its Transcriptomic Basis

The rotating rod fatigue tester adopts the rotating rod tester from Xinruan Company, with animal movement time as the experimental indicator. If the animal falls off, the instrument will automatically record the animal's persistence time on the rotating rod and the speed of the rotating rod at the moment of sliding. Because the coordination of mice is determined by their central nervous system, mice with poorer coordination will fall off the spinning stick in a shorter period of time. The rotational fatigue tester is considered a very important indicator for drug evaluation in Parkinson's disease, alcohol dependence, Huntington's disease, intellectual development, motor disorders, and Alzheimer's disease. The various symptoms of ASD are closely related to functional abnormalities in the striatal brain region. RNA sequencing data: Mice were euthanized with lethal doses of isoflurane after behavioral analysis. Quickly retrieve the target brain tissue and store it in liquid nitrogen for quick freezing. Send it to Jinweizhi Company for sequencing, and save the relevant quality inspection documents and sequencing results to the research team's cloud storage.