HISTAMINE RECEPTORS IN ORAL CANCER: MECHANISMS, CARCINOGENESIS, AND THERAPEUTIC POSSIBILITIES – A SYSTEMATIC REVIEW

Mast cells and their degranulation products play a key role in the pathogenesis of cancer, with histamine, being a key factor in carcinogenesis through its four distinct receptors. Research has shown that the expression of these receptors in malignant tissues triggers a variety of effects that modulate cancer cell behavior. However, there is lack of definitive evidence elucidating the precise mechanisms behind their involvement. This review aims to provide an overview of the current understanding of histamine receptors in oral carcinogenesis and highlight potential directions for future research in this field. A literature search in Medline provided 27 articles for key terms, histamine receptors and oral cancer. Eight articles relevant to the search terms conducted studies on expression of histamine receptors in oral cancer. The present review indicated a strong role of histamine receptors in oral carcinogenesis and suggests to generate new evidence on high scales. Therapeutic interventions employed in the form of inhibitors for these receptors may provide a promising breakthrough in cancer management.