SELECTION OF A STABILIZING MEDIUM FOR HUMAN RESPIRATORY SYNCYTIAL INFECTION VIRUS

This paper presents the results of a study on the selection of a stabilizing medium for the human respiratory syncytial virus (RSV). Studies were conducted using various stabilizing media used in biotechnology, examining their effects on the storability of the studied virus during storage under different temperature and time conditions, followed by determination of the residual biological activity of virus samples in a continuous Vero cell culture. The study found that all virus samples containing peptone, sucrose, gelatin, and their mixtures at low temperatures (minus 40 °C and plus 4 °C) had a beneficial effect on virus storability, whereas high temperatures (plus 37 °C and 22 °C) reduced the biological activity of the RSV. These data are important for the storage, transportation, and use of the virus in the development of diagnostic and vaccine preparations against this infection.