Role of NRF2 in regulating oxidative stress and alleviating mitochondrial and endoplasmic reticulum structural damage in heatstroke-induced brain injury

World Journal of Emergency Medicine 2026 Open access

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Authors: Bingling Yin, Haiyang Guo, Yu Shao, Chongxiao Xu, Yueli Zhao, Ting Chen, Xuan He, Shan Sun, Caoyuan Wu, Guodong Lin, Zhiguo Pan
DOI: 10.5847/wjem.j.1920-8642.2026.026
Cited by: 2
References: 40

Abstract

This preliminary research shows that the NRF2 antioxidant signaling pathway exerts a protective effect against oxidative stress, mitigating both mitochondrial and ER structural damage in neuronal cells during heatstroke. Therefore, targeting the NRF2 pathway is a promising therapeutic strategy for heatstroke-induced neuronal injury.

Fields of Study & Subjects

Thermoregulation and physiological responses Thermal Regulation in Medicine Genomics phytochemicals and oxidative stress

Publication details

Journal / source
World Journal of Emergency Medicine
Publisher
World Journal of Emergency Medicine
Volume
17
Issue
2
Pages
113–113
Publication date
1 January 2026
Language
EN