ADVANCED NOVEL DRUG DELIVERY STRATEGIES FOR ENHANCING BIOAVAILABILITY OF POORLY WATER-SOLUBLE DRUGS

Novel drug-delivery systems (NDDS) are engineered platforms designed to enhance therapeutic efficacy by improving the pharmacokinetics, targeting precision, and safety profiles of active pharmaceutical ingredients. Recent advances—such as nanoparticle-based carriers, stimuli-responsive hydrogels, and ligand-directed delivery—enable controlled release, reduced systemic toxicity, and improved patient compliance. These technologies also support personalized medicine through tunable formulations optimized for specific disease pathways. Overall, NDDS represent a transformative approach to modern therapeutics, offering improved bioavailability and targeted action across a wide range of clinical applications.