ADVANCES IN BIOPHARMACEUTICS AND PHARMACOKINETIC MODELING: INTEGRATING COMPUTATIONAL INSIGHTS INTO DRUG DELIVERY SCIENCE

The scientific base to the relationship between the drug formulation, absorption, distribution, metabolism and excretion are based on biopharmaceutics and pharmacokinetic (PK) modeling. During the last ten years, computational modeling, physiologically based pharmacokinetic (PBPK) simulations, and quantitative systems pharmacology (QSP) have developed remarkable advances, which result in the data-driven optimization of the drug delivery systems. These tools combine experimental results, in silico modeling, and mechanistic understanding to achieve human pharmacokinetic and simplify the formulation design as well as minimizing on animal outcomes. This chapter is the detailed discussion of current development of biopharmaceutics and PK modeling, including dissolution kinetics, bioavailability, PBPK modeling, machine learning application, and regulatory attitudes. The concept of the importance of the computational and systems-based approaches in the development of modern pharmaceuticals is emphasized with a stress put on the translational usage of oral, parenteral and advanced drug delivery platforms.