Comparison of Low and High Dose Clonidine for Infants Admitted to the Neonatal Intensive Care Unit.

Europe PMC (PubMed Central) 2026 Open access

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Authors: Jacob Kelner, Clare O. Riotte, Ursula Marquis, Jessica Askew, Michael B Brimacombe, Shabnam Lainwala
DOI: 10.5863/jppt-24-00140
Cited by: 0

Abstract

OBJECTIVE: This study compares the efficacy of starting with low-dose vs high-dose enteral clonidine for the treatment of pain, agitation, and opioid withdrawal in high-risk infants admitted to the neonatal intensive care unit (NICU). METHODS: This was a retrospective chart review study of infants admitted to a level IV NICU between September 2014 and December 2022 who were started on enteral clonidine before 50 weeks post-menstrual age (PMA) for pain, agitation, or opioid withdrawal. Data were collected over the first 30 days of clonidine treatment. Infants started on low-dose (LDC:

Fields of Study & Subjects

Pediatric Pain Management Techniques Anesthesia and Sedative Agents Pharmaceutical studies and practices

Publication details

Journal / source
Europe PMC (PubMed Central)
Volume
31
Issue
1
Pages
56–61
Publication date
1 February 2026
Language
EN