Duration of Antibiotic Therapy for Escherichia coli Bacteremia in Infants With Normal Cerebrospinal Fluid Studies and Without Meningitis.

OBJECTIVE: bacteremia with reliable, normal cerebrospinal fluid (CSF) studies and without meningitis is unknown. We evaluated whether treatment duration is associated with infection recurrence or mortality in these infants. METHODS: bacteremia. Exclusion criteria included absence of CSF test results, CSF pleocytosis, positive culture or Gram stain from the CSF, delayed antimicrobial initiation (>2 days), or death/discharge during therapy. Antibiotic duration was categorized as 14 days. Univariable analysis and multivariable logistic regression were used to assess associations between antibiotic duration and 30-day and in-hospital mortality, recurrence of infection, and the combined outcome of recurrence of infection or 30-day mortality. Sensitivity analysis excluded courses