Novel aspects of the chemical bonding nature in corrinoiddependent enzymes during biochemical processes in the human body

The scientific novelty and originality of this paper lie in the discovery of crucial aspects of the chemical bond concept in the studied biochemical compounds. These include the vibronic nature of vitamin B12-dependent bioprocesses, their control by the Pseudo-Jahn-Teller effect, the absence of energy barriers during their development, and the long-distance interactions between reagents. The paper also highlights unusual features of the electronic structure of these compounds, such as the formation of intermolecular orbitals between two molecules at 4-5 Å and orbital mixing at large distances between interacting molecules. Additionally, it discusses the transfer of electronic densities or electrons between two molecules at these intermolecular distances, which leads to catalysis of enzymatic processes, spin-dependent biochemical reactions, and other phenomena. This discovery opens new horizons in understanding chemical bonding in the bio-compounds and related fields.