Rare Adolescent Presentation of a Large Well- Differentiated Non-Functional Pancreatic Neuroendocrine Tumor

Pancreatic neuroendocrine tumors (PNETs) are rare pancreatic neoplasms and are even more uncommon in adolescents. Large PNETs often manifest with mass effect or complications, yet they may occasionally present with minimal symptoms or even discovered incidentally. We report an exceptional case of a 17-year-old girl who presented with minimal epigastric pain and was found to have a large, well-defined 9-cm mass arising from the pancreatic head. Exploratory laparoscopy with biopsy confirmed a well- differentiated Grade I non-functional PNET. The lesion was considered unresectable, and the patient was referred for systemic therapy. This case is remarkable for the young age at presentation and the unusually large tumor size despite minimal symptoms, highlighting the importance of considering pancreatic tumors in the differential diagnosis of subtle abdominal symptoms in young patients.