The diagnostic value of serum neuroapoptosis-regulating invertase (NARC1), von Willebrand factor (vWF), and protein G3a levels in type 2 diabetes patients with macrovascular lesions

Background: To evaluate the diagnostic value of serum Neuroapoptosis-regulating invertase (NARC1), von Willebrand factor (vWF), and Protein G3a levels in type 2 diabetes patients complicated with macrovascular lesions. Methods: The type 2 diabetes group consisted of 420 patients with the disease who were admitted to the hospital between January 2021 and June 2024. One hundred fifty healthy people who visited this hospital for checkups during the same time frame were selected for the healthy control group. Based on the diagnostic criteria for macrovascular disease, individuals with type 2 diabetes were split into two groups: 236 patients with uncomplicated diabetes and 184 patients with macrovascular disease. Changes in serum NARC1, vWF, and Protein G3a levels were observed in each group. Serum NARC1, vWF, and Protein G3a levels in individuals with type 2 diabetes were compared before and after treatment using univariate analysis, and the diagnostic efficacy of these three indicators for macrovascular disease in patients with type 2 diabetes was assessed. Results: Serum NARC1 and vWF levels were significantly greater in the type 2 diabetes group, although serum Protein G3a levels were significantly lower (P