The role of serum ITF, IBA-1, and Calgranulin B levels in the early diagnosis and prognosis of cervical cancer

Background: To explore the clinical value of serum Intestinal Trefoil Factor (ITF), Ionized Calcium-Binding Adapter Molecule 1 (IBA-1), and Calgranulin B levels in the early auxiliary diagnosis and prognostic evaluation of cervical cancer. Methods: The cervical cancer group consisted of 256 patients who received a cervical cancer diagnosis at this hospital between January 2023 and June 2024. One hundred fifty people who were diagnosed with cervical intraepithelial neoplasia (CIN) at this hospital within the same time period made up the CIN group. Ninety women who underwent health checks at this facility during the same time period comprised the healthy control group. The diagnostic effectiveness of serum ITF, IBA-1, and Calgranulin B levels in patients with cervical cancer, as well as their correlations with clinical indicators and prognosis, were examined, along with changes in these levels across groups. Results: The cervical cancer group's blood ITF, IBA-1, and Calgranulin B levels were significantly higher than those of the CIN and healthy control groups. Compared to the healthy control group, the CIN group's serum ITF, IBA-1, and Calgranulin B levels were considerably higher (P