Identification of new markers for poor recovery in inflammatory bowel disease based on intestinal barrier function and inflammatory stress response

Background: Inflammatory bowel disease (IBD) is one of the common diseases in the department of gastroenterology. We conducted a cross-sectional study of 74 IBD patients admitted to our hospital from January 2024 to April 2025, focusing on changes in serum cytokines. Subsequently, based on these cytokines, we developed a novel risk model for poor recovery in IBD. Methods: Based on sample size estimation and screening for inclusion and exclusion criteria, we included 74 IBD patients as research subjects (January 2024 to April 2025) for a cross-sectional survey. Key indicators were measured, including intestinal barrier markers (I-FABP, DAO, FC), inflammatory cytokines (IL-6, TNF-a, IL-10), Th17/Treg ratio, and stress hormones (Cor, ACTH). Subsequently, logistic regression was used to develop a risk model to predict poor patient recovery. Results: Patients with IBD exhibit significant impairment of intestinal barrier function: intestinal barrier integrity markers I-FABP, DAO, and FC declined by 31.42%, 45.11%, and 37.31%, respectively (P