Tislelizumab and Pentostatin therapy reverse aggressive T-LGLL with near tetraploid karyotype
Abstract
Dear Editor,T-cell large granular lymphocytic leukemia is an indolent leukemia with no standard treatment for its aggressive variants.We report a 26-year-old Chinese male with T-cell Large Granular Lymphocyte Leukemia (T-LGLL) progressing to aggressive T-LGLL with a near tetraploid karyotype.After conventional chemotherapy failed, he achieved complete remission with Tislelizumab and Pentostatin.No relapse occurred during six months of follow-up, suggesting a potential role for immunotherapy in managing aggressive T-LGLL.
Fields of Study & Subjects
Acute Myeloid Leukemia Research
Chronic Lymphocytic Leukemia Research
Lymphoma Diagnosis and Treatment
Publication details
- Journal / source
- The Innovation Medicine
- Volume
- 4
- Issue
- 2
- Pages
- 100202–100202
- Publication date
- 1 January 2026
- Language
- EN