CuI-Catalyzed C—C Bond Coupling Reaction for the Construction of 2-Carbonyl-1,4-diketones

Transition metal-catalyzed C-C coupling reactions are a core strategy for the construction of carbon-carbon bonds in organic synthesis.Their development has not only promoted the synthesis of drugs, materials, and natural products, but also promoted the development of new synthetic methods, and has also made breakthroughs in mechanism innovation and catalyst design.On this basis, a copper-catalyzed radical reaction between ketones is reported, enabling the synthesis of 2-carbonyl-1,4diones.The method exhibits excellent applicability to multiple structural types of ketones, including aliphatic ketones with diverse substituents, aromatic ketones, and various simple ketones not limited to acetone, with wide applications, easy implementation, low catalyst toxicity, and low cost, cost-effective, and the product is easy to separate and purify.