Copper-Catalyzed Cyclization Reaction of 3-Nitrochromenes with Enaminones to Synthesize of 2 H -Chromeno-pyrrole Derivatives
Abstract
Chromeno-pyrrole derivatives exhibit a wide range of biological and pharmacological activities.Herein, a novel approach to the synthesis of molecular diversity 2H-chromeno-pyrrole has been developed from [3＋2] cyclization of 3-nitrochromenes.The reaction is catalyzed by CuI with 2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidine (DBN) as the promoter at room temperature.This reaction has the advantages of good functional group compatibility, broad substrate universality, and mild reaction conditions.
Fields of Study & Subjects
Multicomponent Synthesis of Heterocycles
Synthesis and Characterization of Pyrroles
Synthesis of Organic Compounds
Publication details
- Journal / source
- Chinese Journal of Organic Chemistry
- Volume
- 46
- Issue
- 2
- Pages
- 496–496
- Publication date
- 1 January 2026
- Language
- EN