Identification of Hub genes in melasma using integrated transcriptomic analysis

Melasma is a prevalent pigmentary disorder or hyper melanosis skin condition. It is characterized by evenly distributed hyperpigmented regions on the light exposed areas of the facial regions. Its management continues to be a therapeutic challenge due to the limited understanding of their pathogenesis. Therefore, it is of interest to report the molecular mechanism of melasma pathogenesis. By using the identification of key genes and pathways via integrate microarray datasets. These transcriptomics studies showed the complex multifactorial molecular mechanisms are involved in melasma production. These key pathways that are involve in oxidative stress, inflammatory signaling and dermal remodeling. This could give insights into a potential therapeutic target such as DNA repair regulators and metabolic stabilizers.