An update on articaine use in dentistry
Abstract
Articaine hydrochloride is considered a highly effective and reliable local anesthetic in dentistry owing to its unique pharmacological characteristics. Its thiophene ring and ester group enhance lipid solubility, ensuring rapid tissue diffusion and efficient hydrolysis that limit systemic toxicity. The 4% formulation offers quicker onset, extended pulpal and soft tissue anesthesia and superior bone penetration compared with lidocaine, mepivacaine, and prilocaine. Recent advancements such as buffered formulations, antibacterial modifications and needle-free systems have further broadened its potential applications. This contributes to high procedural efficiency, improved patient comfort and prolonged anesthetic effects.
Fields of Study & Subjects
Dental Anxiety and Anesthesia Techniques
Dental Research and COVID-19
Pediatric Pain Management Techniques
Publication details
- Journal / source
- Bioinformation
- Publisher
- Biomedical Informatics
- Volume
- 22
- Issue
- 1
- Pages
- 102–106
- Publication date
- 31 January 2026
- Language
- EN