Comparative evaluation of open flap debridement with or without injectable platelet-rich fibrin in chronic periodontitis treatment

Periodontitis, particularly generalized Stage III Grade B periodontitis with intrabony defects, presents significant challenges in treatment, requiring innovative adjunctive therapies to enhance the effectiveness of conventional treatments such as open flap debridement (OFD). Hence, twenty-four patients were randomized to receive OFD alone or OFD + i-PRF. The results showed significant improvements in clinical parameters and radiographic defect fill at 6 months in i-PRF group. I-PRF demonstrated superior outcomes in probing pocket depth reduction and relative attachment level gain. It offers a promising, biocompatible, cost-effective approach for periodontal regeneration. Thus, the of effect i-PRF's as an adjunct to open flap debridement, showing significant improvements in clinical and radiographic outcomes for Stage III Grade B periodontitis with intrabony defects is reported.