Comparative study of histological tumor markers (p53, Ki-67, EGFR) in grading and prognostication of oral squamous cell carcinoma

Bioinformation 2026 Open access

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Authors: Lubna Nazneen, Prateek Mishra, Anushree Rathore, Mahesh Rajashekhara, Dakshayani Vijay Patil, Tarang Mehta, Miral Mehta
DOI: 10.6026/973206300220470
Cited by: 2

Abstract

Oral squamous cell carcinoma (OSCC) outcomes require molecular markers beyond histological grading for reliable prognostication. Therefore, it is of interest to assess p53, Ki-67 and EGFR expression via immunohistochemistry in 96 confirmed OSCC cases, correlating with grade, lymph node metastasis and stage. All markers showed significantly elevated expression with advancing tumor grade (p53 in 78.1%, Ki-67 >50% in poorly differentiated tumors, EGFR in 71.9% of cases). Combined positivity offered superior correlation with lymph node metastasis (p

Fields of Study & Subjects

Head and Neck Cancer Studies Oral Health Pathology and Treatment Cancer-related Molecular Pathways

Publication details

Journal / source
Bioinformation
Publisher
Biomedical Informatics
Volume
22
Issue
1
Pages
470–476
Publication date
31 January 2026
Language
EN