Comparative evaluation sealing ability: Bioceramic versus resin-based sealers by micro-CT analysis

Achieving a hermetic three-dimensional seal of the root canal system remains a primary objective of endodontic therapy, yet comparative evidence on the sealing efficacy of contemporary bioceramic and resin-based sealers remains limited. Therefore, it is interest to compare the sealing ability of three bioceramic sealers (Bio-C Sealer, CeraSeal and EndoSequence BC Sealer HiFlow) with two resin-based sealers (AH Plus and ThermaSeal Plus) using micro-computed tomography. Seventy-five extracted single-rooted human premolars were obturated using single-cone technique for bioceramic sealers and warm vertical compaction for resin-based sealers, followed by three-dimensional assessment of void volume and sealer adaptation. Bioceramic sealers demonstrated significantly lower total void percentages (0.89-1.24%) compared with resin-based sealers (1.78-2.15%) (p < 0.001), with EndoSequence BC Sealer HiFlow showing the best adaptation and lowest void volume. Thus, we show that contemporary bioceramic sealers provide superior sealing ability and canal wall adaptation compared with resin-based sealers, supporting their clinical use for predictable root canal obturation.