Genetic Epidemiology Network of Arteriopathy (GENOA): GWAS Studies

This substudy phs001401 GENOA GWAS Studies, contains genome-wide genetic variants on a subset of participants in the GENOA Cohorts. A total of 1385 European American and 1263 African American participants from GENOA were genotyped on the Affymetrix Genome-Wide Human SNP Array 6.0 array using the protocol outlined by Affymetrix (Affymetrix, 2007) at the Mayo Clinic in Rochester, Minnesota, or at the Broad Institute for a subset (N=92) of African Americans. Some of the stored blood samples contained DNA of poor quality, and we were unable to genotype these samples using the Affymetrix 6.0 platform. However, we were able to obtain high quality genotyping using the Illumina Human1M-Duo or Human660W-Quad BeadChips (Illumina, 2010) for an additional 123 European Americans and 269 African Americans. For all genotyping platforms used, samples and SNPs with a call rate