Clinical and Genetic Correlates of the Gut Microbiome and Relation to Cardiometabolic Risk

The human gut harbors trillions of microbes that play dynamic roles in health. While the microbiome contributes to many cardiometabolic traits by modulating host inflammation and metabolism, there is an incomplete understanding regarding the extent and mechanisms by which individual microbes impact risk and development of cardiovascular disease (CVD). The Framingham Heart Study (FHS) is a multi-generational observational study following participants over decades to identify risk factors for CVD by correlating genetic and phenotypic factors with clinical outcomes. As a large-scale population-based cohort with extensive clinical phenotyping, FHS provides a rich landscape to explore the relationships between the gut microbiome and cardiometabolic traits Available Data sets Currently we have the following data set available in the 'Authorized Access' area of dbGaP. 1. Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol This data set, consisting of metagenome FASTQ data from 624 FHS participants, was released in conjunction with PMID: [32544460](https://pubmed.ncbi.nlm.nih.gov/32544460/).