Immunopathogenesis of Emerging Arboviral Infections and Their Impact on Maternal–Fetal Health
Abstract
This dissertation uses nonhuman primate models to define how emerging arboviruses disrupt placental function and threaten fetal health. Through comparative studies of Zika virus strains and evaluation of a virus-like particle vaccine, this work identifies key mechanisms underlying congenital disease and pregnancy loss. The development of a contemporary O’nyong-nyong virus model further expands these findings to support vaccine development and epidemic preparedness.
Fields of Study & Subjects
Mosquito-borne diseases and control
Virology and Viral Diseases
COVID-19 Impact on Reproduction
Publication details
- Journal / source
- OHSU Digital Commons
- Publication date
- 1 January 2026
- Language
- EN
- Document type
- Thesis