Mumford et al 2022 Fig6 Western Blots

Figure 6: Duplication of Dp3Tyb region is sufficient to raise the protein abundance of DYRK1A in the cortex but does not significantly alter BACE2, FL-APP or CTF abundance. The abundance of (A-B) DYRK1A, (A, C) BACE2, (D, E) full-length, APP (FL-APP), (D, F) C-terminal fragment-α (CTF-α) and (D, G) C-terminal fragment-β (CTF-β) relative to β-actin loading control was measured by western blot in the cortex at 3-months of age in male and female mice. Full uncropped blots