DATA: Steiner et al 2023. Neural signatures of indirect pathway activity during subthalamic stimulation in Parkinson’s disease

Fig 2: To analyze the relationship between ERNA waveform peaks and neuronal firing, stimulation trains at 100 Hz were applied at 30, 50, and 100 μA stimulation intensities for 10 seconds each at a total of 20 recording locations with well-isolated single-neuron activity. Fig 3: Temporal dynamics of ERNA were studied at the beginning of stimulation trains at 100 Hz stimulation frequency at a total of 12 recording locations (100 μA stimulation intensity). At these recording locations, stimulation was also applied at 10, 20, 30, and 50 Hz stimulation frequencies to investigate frequency-specificity. Fig 5: To investigate the topographic organization of ERNA across the spatial extent of STN, stimulation was delivered along the surgical trajectory in 0.5 mm increments.