Fragment-based discovery reveals unprecedented ligandability and enables direct targeting of the melanoma oncogene MITF

Figshare 2026 Dataset Open access

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Authors: Wolfgang Jahnke, Deborah Castelletti, Jürgen Hinrichs, G. Malojcic, Fei Ji, Aurore Desplat, Christelle Henry, Fanny Mermet‐Meillon, Markus Wartmann, Emmanuelle Wirth, Cecile Delmas, César Fernández Fernández
+20 more Niko Schmiedeberg, Simone Plattner, Jvan Brun, Stephan Kläusler, Fanny Schaeffer, Marc Altorfer, Nikoletta Piperidou, Nicolas Pautrieux, Frédéric Baysang, Amanda Cobos‐Correa, Anna Vulpetti, Bryn Marie Reimer, Philipp Mayer, Jessica Kurmann, Kelly Yan, John Fuller, Rainer Wilcken, Martin Renatus, Katie Porter, Markus Kaufmann
DOI: 10.6084/m9.figshare.27879849
Cited by: 0

Abstract

Please see our github deposition for the revised MD simulations (see also manuscript text)

Fields of Study & Subjects

Computational Drug Discovery Methods Protein Degradation and Inhibitors Melanoma and MAPK Pathways

Publication details

Journal / source
Figshare
Publication date
1 January 2026
Document type
Dataset