Data files associated with A Dependency Map Enhanced with Next-Generation 3D Cancer Models

This file set includes metadata files (6 files) and analysis result files (29 files) associated with Neiswender, Maffa, Brenan et al. "A Dependency Map Enhanced with Next-Generation 3D Cancer Models" (Nature, 2026). The custom analysis code used for generating these results is available at a GitHub repository (https://github.com/broadinstitute/DepMap-NextGen-Public). In addition, raw profiling data of the models (including data for mutation, copy number, gene expression, and CRISPR dependency scores) and processed data files required for running the custom code are available at DepMap portal (https://depmap.org/portal/data_page/?tab=allData; file set name "NextGen Model Manuscript 2026"). For more information, please see README.txt.