S3 Fig. Stimulation with a gradient of PRT4165.

Related to Fig 2C. (A, B) WT peritoneal macrophages were treated with increasing concentrations of the histone H2A ubiquitination inhibitor PRT4165 for 4 h, followed by LPS stimulation for 4 h. IL-1β and IL-6 mRNA expression was quantified by RT-PCR. The data are expressed as means ± SDs. Statistical analysis was carried out using one-way ANOVA. The datawereconsidered statistically significant when P ≤ 0.05 (*), P ≤ 0.01 (**). https://doi.org/10.6084/m9.figshare.30581573.