Dataset of Local-Based Ready-to-Use Therapeutic Foods (RUTFs) vs. Standard RUTFs: Which One is Better to Improve Severe Acute Malnutrition (SAM) in Children?

This study presents a systematic review evaluating the effectiveness and acceptability of locally produced ready-to-use therapeutic foods (L-RUTF) compared with standard ready-to-use therapeutic foods (S-RUTF) in the treatment of severe acute malnutrition (SAM) among children aged 6–59 months. The review synthesizes evidence from randomized controlled trials conducted in low- and middle-income countries, where SAM remains a major public health challenge and reliance on imported therapeutic foods may limit program sustainability.Studies published between 2015 and 2025 were identified through comprehensive searches of PubMed, ProQuest, and Scopus. Eligible trials assessed L-RUTF formulations using locally available ingredients, including cereal–legume blends, soy, mungbean, chickpea, fish-based pastes, and adapted peanut formulations, and reported anthropometric outcomes and/or acceptability measures. Key outcomes analyzed included weight gain, mid-upper arm circumference (MUAC), weight-for-height Z-score (WHZ), and height-for-age Z-score (HAZ), alongside indicators of product acceptability such as consumption rates and sensory evaluation.The findings indicate that L-RUTF achieves anthropometric improvements and acceptability comparable to standard RUTF when formulations meet WHO nutritional and safety standards. This research provides evidence supporting L-RUTF as a viable, culturally appropriate, and potentially cost-effective alternative for SAM management in resource-limited settings.