Additional file 1 of Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults

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Authors: Xue Dong, Paul Aveyard, Xiaochen Yang, M Kivimaki, Shanquan Chen, Joseph Firth, Cynthia Wright Drakesmith, Min Gao
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Abstract

Additional file 1. Figures S1-S5. FigS1 - Directed Acyclic Graph. FigS2 - Flow diagram of study participants. FigS3 - Associations between baseline BMI and mental illness by sex group. FigS4 - Associations between baseline BMI and mental by age. FigS5 - Associations between baseline BMI and mental illness by ethnicity. Table S1-S9. Table S1 - Causal mediation analysis to assess the mediation effect of cardiometabolic disease for observed associations between BMI and incident mental illness risk. Table S2 - Causal mediation analysis to assess the mediation effect of inflammatory and cardiometabolic risk markers for observed associations between BMI and incident mental illness risk. Table S3 - Adjusted associations between BMI category and mental illness excluding the first 5 years of follow-up after the BMI record in individuals with mental illness. Table S4 - Adjusted associations between BMI category and mental illness after excluding individuals over 40 years old at baseline. Table S5 - Adjusted associations between BMI category and mental illness excluding individuals with cardiovascular disease, hypertension, and type 2 diabetes at baseline. Table S6 - Adjusted associations between BMI category and mental illness in individuals who had a BMI record less than 1 year after registration. Table S7 - Adjusted associations between BMI category and SMI using the diagnosis date of SMI as the incident date. Table S8 - Adjusted associations between BMI category and SMI excluding individuals with common mental illness at baseline. Table S9 - Adjusted associations between BMI category and mental illness after imputation.

Fields of Study & Subjects

Schizophrenia research and treatment Tryptophan and brain disorders Cardiac Health and Mental Health

Publication details

Journal / source
Figshare
Publication date
1 January 2026