Opposing effects of T3 and IGF-1 on proliferation of fetal CMCs: Does FOXO1 play a role?

Figshare 2026 Dataset Open access

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Authors: Natasha N. Chattergoon, Samantha Louey, George D. Giraud, Kent L. R. Thornburg
DOI: 10.6084/m9.figshare.30995218
Cited by: 0

Abstract

This study aims to determine the influence of thyroid hormone and IGF-1 on each other in the late-term fetal ovine heart. We propose that FOXO1 is an important mediator of the opposing actions of each hormone's influence on MAPK and AKT pathways and how it affects cardiomyocyte proliferation.These are Supplemental Tables S1-S4. They show daily statistical analysis of hemodynamics (Figure 3).

Fields of Study & Subjects

Congenital heart defects research FOXO transcription factor regulation Thyroid Disorders and Treatments

Publication details

Journal / source
Figshare
Publication date
1 January 2026
Document type
Dataset