Additional file 1 of GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model

Additional file 1 (Supplementary Figure 1. Both tauopathy mouse models show an increase of neuroinflammation markers driven by TAU overexpression. Analysis of (A) Aim2 and (B) Gsdme mRNA levels in hippocampal samples from AAV-TAUP301L mice (light green) and in 8-month-old (light blue) and 10-month-old (dark blue) Tg-TAUP301S mice. (C) Immunostaining of GFAP (red) and IBA1 (green) in the CA3 region of both FTD-TAU models. (D) Quantification of the number of GFAP+ cells. (E) Analysis of Gfap mRNA levels. (F) Quantification of the number of IBA1+ cells. (G) Analysis of Iba1 mRNA levels. Bars represent the mean of 5-7 samples ±SEM. Asterisks indicate significant differences of **p