Additional file 2 of GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model

Additional file 2 (Supplementary Figure 2. GSDMD-deficient mice have decreased TAU-induced neuroinflammation markers compared to WT mice. Analysis of mRNA levels of (A) Aim2 and (B) Gsdme in the hippocampus of Gsdmd+/+ and Gsdmd-/- mice that overexpress TAUP301L on the ipsilateral side. (C) Immunostaining of GFAP (red) and IBA1 (green) in the CA3 region. (D) Quantification of the number of GFAP+ cells and Gfap mRNA levels. (E) Quantification of the number of IBA1+ cells and Iba1 mRNA levels. Analysis of the mRNA levels of (F) Il6, (G) Cxcl5, (H) Tnfa, (I) Cxcr3 and (J) Olr1. Bars represent the mean of 4-5 samples ±SEM. Asterisks indicate significant differences of *p