Additional file 6 of GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model

Additional file 6 (Supplementary Figure 6. NRF2 signaling pathway in hippocampus is not altered by GSDMD deficiency and activated by DMF treatment. Analysis of mRNA levels of (A) Hmox1, (B) Nqo1, (C) Gpx1 and (D) Txn1 in the hippocampus of Gsdmd+/+ and Gsdmd-/- mice that overexpress TAUP301L on the ipsilateral side. Analysis of mRNA levels of (E) Hmox1, (F) Nqo1, (G) Gpx1 and (H) Txn1 in the hippocampus of 8-month-old Tg-TAUP301S mice and WT mice treated with VEH or DMF. Bars represent the mean of 4-5 samples ±SEM. Asterisks indicate significant differences of *p