Additional file 8 of GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model

Additional file 8 (Supplementary Figure 8. The induction of neuroinflammation markers is decreased by the treatment with DMF in the Tg-TAUP301S mouse model. Analysis of (A) Aim2 and (B) Gsdme mRNA levels in the hippocampus of 8-month-old Tg-TAUP301S mice and WT mice treated with VEH or DMF. (C) Immunostaining of GFAP (red) and IBA1 (green) in the CA3 region. (D) Quantification of the number of GFAP+ cells and Gfap mRNA levels. (E) Quantification of the number of IBA1+ cells and Iba1 mRNA levels. Analysis of the mRNA levels of (F) Il6, (G) Tnfa, (H) Cxcr3, (I) Cxcl5 and (J) Olr1. Bars represent the mean of 4-5 samples ±SEM. Asterisks indicate significant differences of *p