Diketopiperazines from marine-derived Exserohilum sp. M1-6

Rui Xu; Jianjian Wang; Changyu Liu; Xuefang Yang; Minjun Chen; Zihan Jin; Shengyan Zheng; P. Li; Cong Wang; Shugeng Cao

doi:10.6084/m9.figshare.30997242.v1

Diketopiperazines from marine-derived Exserohilum sp. M1-6

Figshare 2026 Open access

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Authors: Rui Xu, Jianjian Wang, Changyu Liu, Xuefang Yang, Minjun Chen, Zihan Jin, Shengyan Zheng, P. Li, Cong Wang, Shugeng Cao

DOI: 10.6084/m9.figshare.30997242.v1

Cited by: 0

Abstract

A new diketopiperazine (1) and 11 known compounds (2–12) were isolated from marine-derived Exserohilum sp. M1-6. The structure and the absolute configuration of compound 1 were determined by NMR, HRESIMS and electronic circular dichroism (ECD) data. The pro-angiogenic activity of compounds 2–12 were evaluated on the basis of a zebrafish model. The results showed that compounds 3, 11 and 12 had pro-angiogenic activity at a concentration of 40 μM.

Fields of Study & Subjects

Marine Sponges and Natural Products Microbial Natural Products and Biosynthesis Seaweed-derived Bioactive Compounds

Publication details

Journal / source: Figshare
Publication date: 1 January 2026