Research on the correlation between dietary polyphenols supplementation and serum uric acid by the meta-analysis of randomized controlled trials

Recent studies have indicated that dietary polyphenols may affect serum uric acid (SUA) levels, although the results remain controversial. This study aimed to investigate this relationship through a meta-analysis. A total of 21 RCTs with 1502 participants were included. Polyphenols lementation was classified into flavonoid, stilbene, and curcuminoid groups. When the results of these studies were pooled, polyphenols lementation, particularly flavonoids and anthocyanin mixtures, significantly reduced SUA levels, while stilbenes and curcuminoids showed non-significant effects with current evidence. We specifically recommend long-term (> 8 wks) lementation with minimally processed plant-derived polyphenols in capsule or tablet form. This study is registered with PROSPERO (CRD 42023476304).