Data from: Association of prenatal glycemic marker cumulative exposure with placental DNA methylation change

Background: Maternal glycemic dysregulation during pregnancy increases the risk of pregnancy complications and offspring long-term health outcomes, potentially through DNA methylation alterations. Objectives: To investigate the association between maternal glycemic marker concentration during pregnancy and placental DNA methylation, and to examine whether the methylation changes correlate with neonatal anthropometry. Methods: Cumulative glycemic exposure was estimated using area under the curve for glucose (AUCgluc), insulin (AUCinsl), and glycated hemoglobin (AUCHbA1c), measured at 8–13, 16–22, 24–29, and 34–37 gestational weeks. Placental DNA methylation was measured using an Illumina array and tested for associations with AUCgluc, AUCHbA1c, and AUCinsl for all women and stratified by fetal sex. Correlations of the differentially methylated sites with neonatal anthropometry and placenta weight were also tested. Results: Four sex-specific methylation associations were identified at FDR-adjusted p