Mathematical Modeling of the Mechanism of Action of Tirzepatide and Semaglutide

This is supplemental material for "Quantitative Insights into Tirzepatide and Semaglutide Using Longitudinal Systems Modeling", by B. Yang et al, manuscript in preparation. Supplemental Material.pdf; contains: Figures S1 - S11 Tables S1 - S4Model code file for Monolix: Defines the model for the nonlinear mixed effect modeling software MonolixModel report file; contains Figures 1 - 16 including individual participant fits, prediction vs observation plots and other model performance diagnostics and Tables 1, 2 with estimates of population parameters and goodness of fit measures, respectively.