Supplementary information: Educational disparities in prostate cancer survival: a retrospective cohort study from Mexico City.

Educational disparities in prostate cancer survival: a retrospective cohort study from Mexico CityJesús Gibran Hernández-Pérez, MSc,1,2, Hortensia Reyes-Morales, Dr. en C.,3, Abraham Valenzuela-Sánchez, MSc,1,2, Martin Lajous, PhD,1,4, Francisco Rodríguez-Covarrubias, MD,5, Lucino Iván Espin Arellano, BSc6, Evangelina Morales-Carmona, MSc,6, Hugo Manzanilla-García, MD,7, Luisa Torres-Sánchez, PhD,1 1. Center for Population Health Research, National Institute of Public Health (INSP), Av. Universidad 655, Col. Sta. María Ahuacatitlán, 62100 Cuernavaca, Morelos, México. JGHP: nut.jgibran@hotmail.com: ORCID: 0000-0002-7637-4127, AVS: abrahamvalenzuelasanchez@gmail.com: ORCID: 0000-0002-8974-2347. ML: mlajous@insp.mx ; ORCID: 0000-0002-8471-4128, LTS: ltorress@insp.mx: ORCID: 0000-0002-2902-98812. School of Public Health of Mexico, Av. Universidad 655, Col. Sta. María Ahuacatitlán, 62100 Cuernavaca, Morelos, México.3. Center for Health Systems Research, National Institute of Public Health (INSP), Av. Universidad 655, Col. Sta. María Ahuacatitlán, 62100 Cuernavaca, Morelos, México. hortensia.reyes@insp.mx : ORCID: 0000-0002-9763-41434. Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA5. Departamento de Urología. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), Av. Vasco de Quiroga 15, Col. Belisario Domínguez, Col. Sección XVI, Deleg. Tlalpan, 14080 Ciudad de México, México. frodriguez.covarrubias@gmail.com: ORCID: 0000-0003-0056-78866. Center for Research in Evaluation and Surveys, National Institute of Public Health, Cuernavaca, Mexico. Av. Universidad 655, Col. Sta. María Ahuacatitlán, 62100 Cuernavaca, Morelos, México. LIEA: ciee04@insp.mx; ORCID: 0000-0002-3730-7677. EMC: evangelina.morales@insp.mx: ORCID: 0000-0002-5186-4605.7. Departamento de Urología, Hospital General de México. Mexico City, Mexico. Email: hamanzanilla@gmail.com: ORCID: 0009-0002-3445-3158 Corresponding authors:Dra. Luisa Torres-Sánchez. National Institute of Public Health (INSP, it is acronym in Spanish), Av. Universidad 655, Col. Sta. María Ahuacatitlán, 62100 Cuernavaca, Morelos, México. Phone: +52 777 329 3000, ext 3454. Email: ltorress@insp.mx: ORCID: 0000-0002-2902-9881 Contents Supplementary Figure 1. Directed acyclic graphs (DAGs) illustrate the association between education and Prostate Cancer (PC) mortality.2Supplementary Table 1. Comparison of included and excluded participants at baseline and in sensitivity analysis.......................................................................................................................................................................4Supplementary table 2. Fully adjusted association between educational attainment and prostate cancer–specific mortality using Cox proportional hazards models among men with prostate cancer in Mexico City, 2011–2021.......6Supplementary Table 3. Adjusted prostate cancer–specific survival (95% CI) at 5 and 8 years according to testing reason (combined, PSA, and DRE), overall and by educational level......................................................... 7Supplementary Table 4. Adjusted hazard ratios (HRs) for prostate cancer–specific mortality by education level under three modeling scenarios: (1) competing risk model, (2) truncated follow-up in 2019, and (3) excluding participants who died within the first two follow-up years............................................................................................8