Challenges to case-only analysis for interaction detection using polygenic risk scores: model assumptions and biases in large biobanks

Scripts for simulation and real data analyses.Analysis_log_*.R: Codes for generating simulated data under the piecewise log-linear model; Numbers in file names correspond to the parameters in Supplementary Tabe S2.Analysis_logit_*.R: Codes for generating simulated data under the logistic model; Numbers in file names correspond to the parameters in Supplementary Tabe S2.Analysis_probit_*.R: Codes for generating simulated data under the liability threshold model; Numbers in file names correspond to the parameters in Supplementary Tabe S2.UKB_analysis.R: Codes for real data analyses in the UK Biobank.