Additional file 1 of A comparison of prostate cancer detection rates between TRUS-GB and MRI-GB: a systematic review and meta-analysis

Supplementary Material 1: Online resource 1: Detailed baseline data of the included studies. Online resource 2: Diagram of Risk of Bias assessment in non-randomised trials using theROBINS-I tool. Online resource 3: Subgroup analysis of randomized controlled trials (RCTs) only, assessingthe outcomes of overall prostate cancer (PCa) detection rates (1.1), clinicallysignificant prostate cancer (csPCa) detection rates (1.2), and clinicallyinsignificant prostate cancer detection rates (1.3). Online resource 4: Subgroup analysis of studies with no contamination of systematic biopsiesin the intervention group, assessing the outcomes of overall prostate cancer(PCa) detection rates (1.1), clinically significant prostate cancer (csPCa)detection rates (1.2), and clinically insignificant prostate cancer detection rates(1.3). Online resource 5: Subgroup analysis of overall prostate cancer (PCa) detection rates stratified bybiopsy technique subtypes, including (1.1) mpMRI-guided biopsy (mpMRI-GB)subtypes (cognitive, fusion, and in-bore) and (1.2) US-guided biopsy (US-GB)approaches (transrectal and transperineal). Online resource 6: Subgroup analysis of clinically significant prostate cancer (csPCa) detectionrates stratified by biopsy technique subtypes, including (1.3) mpMRI-guidedbiopsy (mpMRI-GB) subtypes (cognitive, fusion, and in-bore) and (1.4)US-guided biopsy (US-GB) approaches (transrectal and transperineal). Online resource 7: Subgroup analysis of clinically insignificant prostate cancer detection ratesstratified by biopsy technique subtypes, including (1.5) mpMRI-guided biopsy(mpMRI-GB) subtypes (cognitive, fusion, and in-bore) and (1.6) US-guidedbiopsy (US-GB) approaches (transrectal and transperineal). Online resource 8: Subgroup analysis of missed diagnostic rates stratified by biopsy techniquesubtypes, including (1.7) mpMRI-guided biopsy (mpMRI-GB) subtypes(cognitive, fusion, and in-bore) and (1.8) US-guided biopsy (US-GB)approaches (transrectal and transperineal).