Supplementary Material for: Magnetocardiography for Distinguishing Obstructive Coronary Heart Disease and Coronary Microvascular Dysfunction: A Feasibility Study

‌Objective‌ To evaluate the capability of magnetocardiography (MCG) in distinguishing obstructive coronary heart disease (OCHD) from coronary microvascular dysfunction (CMVD). Methods Patients with chest pain suspected of having CAD were consecutively enrolled in according to the inclusion and exclusion criteria, All patients underwent coronary angiography and coronary blood flow analysis, and were divided into OCHD group (n=447) and CMVD group (n=332) based on the results of imaging analysis. All patients also underwent MCG examination before or after coronarg angiology in 48 hours, the magnetocardiography (MCG) parameters were analyzed by an independent third party. Univariate and multivariate logistic regression analyses were performed to identify significant clinical and MCG parameters between groups. Diagnostic models were constructed using selected MCG parameters alone or in combination with clinical indicators. Performance was assessed using receiver operating characteristic (ROC) curves, accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Clinical utility and model performance were further validated via calibration curves and decision curve analysis. ‌Results In OCHD group, the prevalence of type 2 diabetes mellitus (T2DM) (35.79% vs. 25.30%, p=0.022) and interventricular septal thickness (mm) [11.00 (10.25-12.00) vs. 11.00 (10.00-11.00), p