Processed data of AGS patients' PBMS and AGS cellular models (scRNAseq, metabolomic)

The present zip file contains processed data of scRNA-seq (rds file after Seurat processing) and metabolomics (LC/MS targetted metabolite relative quantification normalized to the median) from patients' PBMCs with Aicardi-Goutières syndrome and from AGS cellular models linked to the scientific article entitled "Pharmacological stabilization of hypoxia-inducible factor 1-alpha dampens the interferon response while favoring glycolysis pathway in Aicardi-Goutières syndrome" Batignes et al. accepted in Nature Communications in january 2026.rds file (scRNA-seq):"Integration#1.rds"= integration of AGS2, ASG6, COPA and CTRL samples"Integration#2.rds"= integration of AGS5 and CTRL samples"SeuratObject_IFN_16jan2023"=integration of healthy donor PBMC stimulated with type I IFN at indicated timepoints. It also contains other files recquired to reproduce figure panels.