Spatial single-cell proteomics (64-plex) of colonic mucosal tissue of CD patients in remission and non-IBD controls

Figshare 2026 Dataset Open access

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Authors: Annika Raschdorf, Larissa Nogueira de Almeida, Philipp Solbach, Martha Maria Kirstein, Jens U Marquardt, Franziska Schmelter, Ulrich L. Günther, Heidi Schlichting, Maren Hicken, Lea Christiansen, Miriam Wiestler, Hauke Christian Tews
+14 more Dominik Bettenworth, OUTLIVE-CRC consortium, Matthias Peipp, Thomas Valerius, Mohab Ragab, Thorben Sauer, Timo Gemoll, Marc Ehlers, Philip C Rosenstiel, Rudolf Armin Manz, Axel Künstner, Hauke S. Busch, Christian Sina, Stefanie Derer
DOI: 10.6084/m9.figshare.31057111
Cited by: 0

Abstract

Related publication: "Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease", 2026, Raschdorf et al., Nature CommunicationsSpatial single-cell proteomics data were generated in two separate experiments on the CosMx platform (Bruker) using the 64-plex Human Immuno-Oncology protein panel. FFPE fixed slices of colonic biopsies from patients with Crohn's disease (CD) in remission (n = 6) and non-IBD controls (n = 6) were analyzed.

Fields of Study & Subjects

Inflammatory Bowel Disease Single-cell and spatial transcriptomics Multiple Sclerosis Research Studies

Publication details

Journal / source
Figshare
Publication date
1 January 2026
Document type
Dataset