Simple, efficient and one-pot synthetic protocol for highly versatile 4-formylpyrazole derivatives: A step toward sustainable development

4-Formylpyrazole derivatives are an important class of building blocks for various heterocycles, including drugs. They have wide applications in the fields of synthetic and medicinal chemistry, in addition to acting as antibacterial, anti-inflammatory, antiparasitic, and anti-diabetic agents. Here, we report a new one-pot synthetic protocol for highly versatile 4-formylpyrazole derivatives in which differently substituted acetophenones and phenyl hydrazine were treated with Vilsmeier–Haack reagent. The present protocol offers a straightforward, highly efficient, practical, and cost-effective approach for synthesizing 4-formylpyrazole derivatives in excellent yields, including an important intermediate of the drug, Lonazolac. All the synthesized compounds were characterized based on spectroscopic data (UV-Vis, 1H, 13C NMR, FT-IR, and Mass).