Supplemental figure 1: Multiple sequence alignment of utilized IP3R isoforms. from Anti-apoptotic BCL-2 binds to all three IP3R isoforms, thereby limiting the Ca2+-flux properties of IP3R homo-tetramers

Ian de Ridder; Claire Cauwelier; Larry E. Wagner; Jens Loncke; Vikas Arige; Irina I. Serysheva; David Yule; Geert Bultynck

doi:10.6084/m9.figshare.31157648

Supplemental figure 1: Multiple sequence alignment of utilized IP3R isoforms. from Anti-apoptotic BCL-2 binds to all three IP3R isoforms, thereby limiting the Ca2+-flux properties of IP3R homo-tetramers

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Authors: Ian de Ridder, Claire Cauwelier, Larry E. Wagner, Jens Loncke, Vikas Arige, Irina I. Serysheva, David Yule, Geert Bultynck

DOI: 10.6084/m9.figshare.31157648

Cited by: 0

Abstract

A: Alignment of the known BCL-2-binding site within the ARM2 domain of all IP3Rs used within this paper. B: Alignment of the ligand binding region (LBR) of IP3R isoform 1 species rat and human. C: Alignment of the LBR of IP3R isoform 3 species rat and human.

Fields of Study & Subjects

Cell death mechanisms and regulation Ion channel regulation and function Ion Channels and Receptors

Publication details

Journal / source: Figshare
Publication date: 1 January 2026