Additional file 2 of Polygenic risk score-guided personalized osteoporosis screening: a population-based study

Additional file 2: Figures S1–S7. Fig. S1-Age-specific 10-year cumulative risk curves in different PRS risk groups. Fig. S2 - The cumulative hazard of osteoporosis in different PRS risk groups at age 65. Fig. S3 - The cumulative hazard of osteoporosis in different PRS risk groups of all female participants. Fig. S4 - Cumulative hazard of osteoporosis in different PRS risk groups of postmenopausal women under 65 with low body weight. Fig. S5 - Age-specific 10-year cumulative risk curves in different PRS risk groups of postmenopausal women under 65 with low body weight. Fig. S6 - Flowchart of osteoporosis fracture risk as the primary outcome for women. Fig. S7 - Flowchart of osteoporosis fracture risk as the primary outcome for men. Table S1-S11. Table S1 - Age-specific 10-year cumulative risk (%) for women over 65 across different PRS risk groups. Table S2 - Age-specific 10-year cumulative risk (%) for women over 65 across different PRS risk groups, accounting for competing risks (loss to follow up and death). Table S3 - Hazard ratio (HR) and Risk advancement period (RAP) in different risk groups based on PRS (Excluding participants with missing covariates). Table S4 - Baseline characteristics for postmenopausal women under 65 with low body weight across different PRS risk groups. Table S5 - Age-specific 10-year cumulative risk (%) for postmenopausal women under 65 with low body weight across different PRS risk groups. Table S6 - Risk advancement period (RAP) and risk-adapted starting age of osteoporosis screening for postmenopausal women under 65 with low body weight across different PRS risk groups. Table S7 - Age-specific 10-year cumulative risk (%) of osteoporotic fracture for women. Table S8 - Age-specific 10-year cumulative risk (%) of osteoporotic fracture for men across different PRS risk groups. Table S9 - Risk advancement period (RAP) and risk-adapted starting age of osteoporotic fracture screening for women across different PRS risk groups. Table S10 - Risk advancement period (RAP) of osteoporotic fracture for men across different PRS risk groups. Table S9 - Risk advancement period (RAP) and risk-adapted starting age of osteoporotic fracture screening for women across different PRS risk groups. Table S10 - Risk advancement period (RAP) of osteoporotic fracture for men across different PRS risk groups. Table S11 - Risk advancement period (RAP) and risk-adapted starting age of OP screening in different risk groups based on PRS using flexible parametric survival models.